New research reveals that people who stop using new GLP-1 drugs like Mounjaro or Wegovy may regain reduced body mass far faster than those who stop conventional diet and exercise plans.
Findings released in a major medical journal demonstrates that while overweight individuals often shed a large proportion of their body weight while on the medication, the mass is regained at an average rate of 0.8 kg per month after stopping.
"Users buying such medications need to be informed of the danger of rapid weight regain when the treatment concludes," cautioned researcher Dr. Susan Jebb.
Such speed of recovery suggests a reversion to pre-treatment weight in about a year and a half.
Comparing Therapies
The research, which reviewed 37 of trials involving over 9,000 of patients, compared the outcomes of these new drugs with other pills.
The team emphasize that people who lose weight through diet and exercise generally experience a more gradual weight regain—approximately 100 grams monthly—post-intervention.
Understanding the Rapid Rebound
Experts propose the way of the jabs accounts for the amplified weight return.
GLP-1 drugs imitate a natural hormone called GLP-1, which helps regulate hunger.
"Long-term administration of the hormone levels far above than the body's typical production may cause the system to generate a reduced amount of its endogenous hormone, and may also reduce sensitivity to its actions," explained Dr. Adam Collins, a dietetics expert.
"Discontinuation of this medication leads to appetite is unsuppressed, making overeating a significant risk."
A Lifelong Issue?
The NHS advise the injections for individuals with obesity-related health risks, alongside prescribed diet and exercise modifications.
Many experts say that, considering the high risk of weight regain, the therapy might need to be long-term.
This opinion is reinforced by pharmaceutical companies, who note that the results "highlight the chronic nature of obesity," comparing it to managing diseases like diabetes.
User Accounts
Individuals who have discontinued the jabs report a powerful return of cravings.
"It felt as if a trigger flipping and you're instantly extremely hungry," said one woman.
This difficulty is worsened if patients have not established lasting lifestyle or habit modifications during treatment.
Growing Use
Figures suggest that millions of people in the UK have used weight-loss jabs in the past year, with demand remaining high.
- Adoption is more common among females compared to men.
- The 40s and 50s demographic shows the greatest usage rates.
- A large proportion obtain the medications through private prescriptions rather than the NHS.
In conclusion, clinicians caution that while these medications are powerful tools for weight loss, they are not a magic fix and lasting health benefits likely depends on integrated lifestyle support.
